Studies on tricarboxylic acid cycle of Trichophyton

Tricarboxylic Acid Cycle in

Studies on the operation of the tricarboxylic acid cycle in scurvy.

Dickmann and Cloutier (1) observed that aconitase is stabilized and activated by ferrous iron and reducing agents such as ascorbic acid or cysteine. This led Takeda and Hara (2) to study the urinary excretion of citric acid and ketone bodies in scorbutic and oc,oc’-dipyridyl-injected guinea pigs after the animals were fed butyrate. These animals excreted increased amounts of citric acid and ket...

Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates

Methylation of lysine-4 of histone H3 (H3K4men) is an important regulatory factor in eukaryotic transcription. Removal of the transcriptionally activating H3K4 methylation is catalyzed by histone demethylases, including the Jumonji C (JmjC) KDM5 subfamily. The JmjC KDMs are Fe(II) and 2-oxoglutarate (2OG)-dependent oxygenases, some of which are associated with cancer. Altered levels of tricarbo...

The Tricarboxylic Acid Cycle in Dictyostelium discoideum

Some aspects of tricarboxylic acid-cycle activity during differentiation and aging in Dictyostelium discoideum were examined. The concentrations of glutamate, aspartate, alanine, citrate, 2-oxoglutarate, succinate, fumarate, malate, oxaloacetate, pyruvate and acetyl-CoA were determined at four stages over the course of differentiation. The rate of 02 utilization was also determined over differe...

Tricarboxylic acid-cycle activity in Streptomyces olivaceus.